A new opinion piece published in Health Affairs Forefront raises questions around current approaches to assess drug safety and effectiveness in people with obesity. The article sheds light on how increased body fat can modify the effects of drugs used to treat common conditions, in some cases rendering the drugs ineffective or unsafe for people with obesity.
raises questions around current approaches to assess drug safety and effectiveness in people with obesity. The article sheds light on how increased body fat can modify the effects of drugs used to treat common conditions, in some cases rendering the drugs ineffective or unsafe for people with obesity.
should be required to show correct dosing instructions on their labels for people with obesity when they are well-known, and when appropriate, include people with obesity in clinical trials during the drug approval process.they take are safe and effective for them," according to William Dietz, Director of the STOP Obesity Alliance at the Milken Institute School of Public Health at the George Washington University, and one of the paper's authors.
For example, brexpiprazole, marketed under the brand name Rexulti, is a drug that treats schizophrenia and depression, two very serious conditions with life-threatening implications. Rexulti is lipophilic. It was approved by the FDA in 2015 without being tested fully on people with obesity, despite the fact that around 60% of people with schizophrenia have obesity.
This lack of information may have serious consequences. For example, people with schizophrenia who are under-treated or who stop treatment may suffer mental health crises or harm themselves or others.fungal infections
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