SINGAPORE: Researchers at the Yong Loo Lin School of Medicine have pioneered a breakthrough method to engineer yeast capable of forming self-regulating microbial communities that adapt to environmen
tal signals.
This development marks a significant leap from traditional microbial biotechnology, constrained by its reliance on single-cell organisms incapable of executing complex, coordinated tasks. “These artificially engineered smart yeast cells could revolutionise how microbial communities are controlled for health purposes,” said Associate Professor Matthew Chang, Director of the Synthetic Biology Translational Research Programme at NUS Medicine and NUS Synthetic Biology for Clinical and Technological Innovation.
Crucially, the yeast reacts to disease markers—molecules that accumulate in the body during illness—allowing it to produce precise amounts of therapeutic compounds as needed. This allows for flexible and precise therapeutic production without manual intervention, improving treatment outcomes.”
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