A research group has found that novel autoantibodies that had been found to cause thrombosis and other conditions in joint research conducted by Kobe and Osaka universities in 2015, are also implicated in pregnancy disorders, including hypertensive disorders of pregnancy and fetal growth restriction.
loss, and infertility, the causes of which are not fully understood, as well as contribute to the development of drugs to treat these conditions.high blood pressure
Women who successfully become pregnant may run the risk of having to undergo a cesarean section at an early stage of pregnancy to protect their own life when diagnosed with hypertensive disorders of pregnancy or fetal growth restriction, losing their baby or having a surviving child with severe disabilities. This exacerbates the issues posed by Japan's declining birthrate.
Subsequently, a multicenter research project led by Kobe University that involved five university hospitals found that about a quarter of 227 women suffering from recurrent pregnancy loss who had repeated miscarriages after becoming pregnant and were unable to carry a healthy baby to term tested positive for these autoantibodies. This suggested that the autoantibodies could be a leading cause of recurrent pregnancy loss, a result reported in a paper published in 2020.
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