Scientists have stumbled upon an extraordinary 'living drug' in the bloodwork of a late-stage cancer survivor.
Despite these incredible results, scientists still don't know how the therapy works on a cellular level.for years, and now, they've had a breakthrough.
When examining the results of phase I and II clinical trials, in which 31 patients with malignant melanoma received TIL therapy, researchers found those who successfully cleared their cancer still showed strong T-cell responses over a year later. The T-cells from one of these patients were remarkably 'multi-pronged', showing the potential to respond to"Importantly, we have seen large numbers of multi-pronged T-cells in the blood of cancer survivors,"To confirm what's really going on, Sewell and his colleagues must now carefully watch these multi-pronged T-cells attack cancer in the lab.
Only then will they be able to determine whether these immune cells are responsible for the great outcomes of TIL therapy. "[W]e hope to investigate whether engineered multi-pronged T-cells can be used to treat a wide range of cancers in a similar way to how engineered
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