How regular physical activity increases your odds of maintaining a 'healthy mind in a healthy body' as you age, according to ckbergland
Maintaining White Matter Integrity via Physical Activity May Help to Offset Age-Related Cognitive Decline
Accumulating evidence suggests that in addition to slowing down gray matter atrophy and the loss of brain volume due to age-related shrinkage, regular physical activity may also help to maintain white matter microstructure integrity as we age. "[Our] analyses are consistent with the notion that brain tissue microstructure, as quantified by postmortem MRI, partially mediates the association between higher levels of physical activity and better cognitive function," Dawe et al. conclude.
That said, like most MRI-based brain imaging studies, the latest paper on"physical activity, brain tissue microstructure, and cognition in older adults" has limitations. Although this study advances our understanding of how"brain tissue microstructure mediates the relation between physical activity and cognition in old age," the researchers acknowledge that more research is needed to"elucidate the molecular mechanisms underlying this pathway.
In terms of future research, the authors note that their recent findings"may help to direct future studies focused on specific brain regions to elucidate the molecular mechanisms underlying this pathway, thereby catalyzing further drug discovery for maintaining cognition."Robert J. Dawe, Lei Yu, Sue E. Leurgans, Bryan D. James, Victoria N. Poole, Konstantinos Arfanakis, Julie A. Schneider, David A. Bennett, Aron S. Buchman.
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