Unlike tirzepatide, which combines weight loss and glucose-lowering properties, this 'twincretin' reduces liver fat along with weight, blood pressure, and lipid levels.
Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit.HAMBURG, Germany ― The investigational incretin receptor agonist pemvidutide produced significant weight loss and other cardiometabolic benefits in a phase 2 randomized trial, adding a different type of"twincretin" to a growing mix of incretin-based weight-loss drugs in development that also offer additional benefits.
Asked to comment, session moderator Rajna Golubic, PhD, of the Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, United Kingdom, told Medscape,"We need to think in terms of treating beyond weight loss.... We need to look at the person holistically and at other aspects of cardiometabolic health and treat in a personalized way and choose treatments according to the comorbidities people have.
In a prespecified interim analysis of 160 participants, the percent body weight loss at 24 weeks was 10.7%, 9.4%, and 7.3% with the 2.4-mg, 1.8-mg, and 1.2-mg doses, respectively . All weight loss values were significant; weight loss with placebo was a nonsignificant 1%.
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