New Study Shows How Dormant Toxoplasma Parasites Manipulate Neurons to Survive biology science
infections can cause congenital birth defects, blindness and neurological dysfunction in unborn children. In adults who are immunocompromised, it can cause blindness and even death.parasites often lay dormant in the brain of the host animal, where they could reactivate to cause severe disease,” said Ushma Ruparel, a Ph.D. student in the Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology at the University of Melbourne.
“IST plays a key role in limiting interferon signaling in bradyzoites, to protect host cells from immune-mediated cell death, which is essential to the body’s fight against,” said Dr. Chris Tonkin, also from the Walter and Eliza Hall Institute of Medical Research and the Department of Medical Biology at the University of Melbourne.
“While the immune system is determined to rid the infection from the body, the parasite only has survival on its mind. So, it’s essentially a tug-of-war, a molecular battle.”
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