The findings could help in the search for novel ways of treating even the most lethal of cancers. Read more at straitstimes.com.
SINGAPORE - A research team led by the National Cancer Centre Singapore has discovered how cancer cells escape detection and destruction by the immune system – a feature that was previously unknown.
Professor Gopal Iyer, senior author of the study and head of the Department of Head and Neck Surgery, Division of Surgery and Surgical Oncology, Singapore General Hospital and National Cancer Centre Singapore, said the immune system searches for and destroys abnormal cells such as cancer cells. The team found pre-metastatic cells within the primary tumours with the capacity to metastasise to the lymph nodes. They also found that a substantial proportion of CD8+ cells, a key component of the immune system that searches for and kills abnormal cells such as cancer cells, were “exhausted” and unable to perform their protective role. This occurred when the immune cells were repeatedly exposed to cancer and unable to eliminate it.
Prof Iyer said that when the Midkine pathway is activated between the cancer cells and the immune cells, the cancer cells are effectively emitting a “don’t eat me” signal.
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