Scientists have developed a method to identify aging muscle stem cells. The issue of aging and the fight against it has long been prevalent in both classic and contemporary literature throughout human history. From the ill-fated Qin Shi Huang's expedition to the sea in pursuit of eternal life to th
If scientists can identify chromatin-modifying regulators that are downregulated in aging stem cells, restoring their expression would be a potential target to prevent aging.The issue of aging and the fight against it has long been prevalent in both classic and contemporary literature throughout human history.
In contrast to their younger counterparts, aging MuSCs have decreased stemness . If the chromatin signature of an aged cell can be restored to that of a young cell, the process of cellular aging—and, in this example, skeletal muscle tissue aging—may be slowed or even reversed.“The regulation of chromatin accessibility is critical for cell fate decisions,” said Professor Cheung. “Changes in the chromatin state can lead to dysregulation of gene expression.
Many possibilities are waiting to be unearthed now that scientists have gained a better understanding of what happens to an aging cell, opening a variety of avenues for anti-aging strategies to be pursued further.
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