A new method to assess the status of immune responses to specific antigens in detail by analysis using the B cell receptor (BCR) repertoire has been developed by a research group, consisting of Assistant Professor Yohei Funakoshi, Associate Professor Kimikazu Yakushijin, Professor Hironobu Minami (Kobe University Graduate School of Medicine), Associate Professor Goh Ohji (Kobe University Hospital), and Researcher Takaji Matsutani (Repertoire Genesis Inc.).
These research results were published online in British Journal of Haematology on June 22, 2023.
However, due to the presence of significant amounts of antibodies from the prophylactic preparations, the reactions after vaccine inoculation cannot be accurately evaluated using the ELISA method. For these reasons, there is a need for an assessment method to evaluate the immune response after vaccine inoculation in these cases, focusing on mRNA levels rather than protein levels.
Specifically, it is considered that the initial immunity is activated at about two weeks after inoculation with mRNA SARS CoV-2 vaccine, and the researchers performed repertoire analysis at about one week after inoculation when additional immunity is considered to be activated . On this occasion, the sequence information derived by repertoire analysis is extremely large, and it is difficult to assess the immunological reaction in respect of specific antigens using repertoire analysis alone.
Further developments The research group termed the newly developed "Assessment method of immunological reaction in respect of specific antigens using repertoire analysis data " as the "Quantification of antigen specific antibody sequence " method . Explanation of terminology 1 Repertoire analysis of B cell receptors: B cells which are the main lymphocytes express B cell receptors which are receptor molecules recognizing antigens. When these receptors bind to antigens such as those of cancer or viruses, the cells are activated, initiating an immune reaction. To be able to react with diverse antigens, diverse BCRs are created by mechanisms of genetic rearrangement and somatic hypermutation.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Work starts on new vet school at University of Central LancashireVisiting the construction site for the new vet school on Preston's university campus Pic: UCLan Work is underway on building a new state-of-the-art vet scho
Read more »
The Ulster University parents' guide to ClearingEverything you need to know
Read more »
Co Tyrone mum-of-two celebrating ahead of return to universityDungannon student Nadia Kelly first went to university to do a social work degree, before coming to the realisation that it wasn’t the right choice for her
Read more »