New method precisely locates gene activity and proteins across tissues WeillCornell NatureBiotech
"This technology is exciting because it allows us to map the spatial organization of tissues, including cell types, cell activities and cell-to-cell interactions, as never before," said study co-senior author Dr. Dan Landau, an associate professor of medicine in the Division of Hematology and Medical Oncology and a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine and a core faculty member at the New York Genome Center.
The other co-senior author was Dr. Marlon Stoeckius of 10x Genomics, a California-based biotechnology company that makes laboratory equipment for the profiling of cells within tissue samples. The three co-first authors were Dr. Nir Ben-Chetrit, Xiang Niu, and Ariel Swett, respectively a postdoctoral researcher, graduate student, and research technician in the Landau laboratory during the study.
The new method is part of a broad effort by scientists and engineers to develop better ways of"seeing" at micro scale how organs and tissues work. Researchers in recent years have made big advances particularly in techniques for profiling gene activity and other layers of information in individual cells or small groups of cells.
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