A new study reveals how early colorectal cancer cells may hide from the immune system, building on growing and crucial research on cancer immune evasion.
Cancer cells survive in the body because they're able to hide from the immune system, evading the cancer-fighting T cells on constant patrol.
Further analysis revealed a transcription factor called SOX17 as key in the cancer's development. SOX17 is a fetal transcription factor, which plays a crucial role in fetal development.More Clues "Every single cell in the body has an interferon-γ receptor," explained Agudo. When IFNγ binds to the receptor, the cells respond by releasing chemokines that call in more T cells and increase antigen presentation so the T cells can recognize the potential threat.
The researchers also looked at human biopsies and found that SOX17 was active in 100% of precancerous polyps and 70% ofHow does a fetal transcription factor turn on in the first place? "That's the one mystery we don't quite understand," Yilmaz said. "That's an area of future active investigation."More research is needed to confirm the study's findings, but if the mechanism holds up, it could lead to new treatments.
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