A new blood test called p-tau217 shows promise as an Alzheimer's disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology. That is an innovation now presented by researchers at the University of Gothenburg, together with colleagues at University of Lund and in Montreal, Canada.
In recent years, a lot of effort has been put on developing biomarkers in blood that could potentially help to identify Alzheimer's disease . Tau protein, in particular its phosphorylated variant —and one of the main proteins involved in AD pathology—has been the focus of extensive research and developments the last years.
However, even if promising, a concern has been that classifying early patients into either having"AD or not AD" will still result in a rather high percentage of false positives andConsidering not only ethical and psychological concerns induced by possible misdiagnosis, but also
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