Penn State researchers have developed a new biosensor that provides scientists with the first dynamic images of manganese, an elusive metal ion that is essential for life. The researchers crafted the sensor using a natural protein called lanmodulin, which has the ability to bind rare earth elemen
Manganese is a chemical element that is commonly found in rocks and soils. It is a hard, brittle, gray-white metal that is often used in steelmaking. Manganese is also an essential nutrient for humans and animals, playing a crucial role in the metabolism of amino acids, cholesterol, and carbohydrates.researchers have developed a new biosensor that provides scientists with the first dynamic images of manganese, an elusive metal ion that is essential for life.
, host-pathogen interactions, and neurobiology. It could also be potentially applied more generally for processes such as the separation of the transition metal components in lithium-ion battery recycling.. She explained that the team was able to monitor the behavior of manganese within bacteria and are now working to engineer even tighter binding sensors to potentially study how the metal works in mammalian systems.
“There are so many potential applications for this sensor,” said Cotruvo. “Personally, I am particularly interested in seeing how manganese interacts with pathogens.” Designing proteins to bind to particular metals is an intrinsically difficult problem, Cotruvo explained, because there are so many similarities between the transition metals present in cells. As a result, there has been a lack of chemical biology tools with which to study manganese physiology in live cells.
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