Network-based approaches often unveil what remains concealed—this holds true in medical research as well. For several years, CeMM Adjunct Principal Investigators Kaan Boztug, Director of St. Anna Children's Cancer Research Institute, and Jörg Menche, a professor at the University of Vienna and Max Perutz Labs have been working to gain a better systemic and molecular understanding of rare diseases, congenital immune disorders, and congenital inflammatory disorders by using network-based methods.
In their latest study led by the study's first author Julia Guthrie, the researchers successfully identified new molecular and mechanistic similarities between rare immune system disorders by examining the high degree of interconnectedness of molecular interactions, leading to their reclassification. By comparing their results to
"Compared to existing clinical data, the new disease classification allows for a much better prediction of promising therapies compared to the previous approach. Network biology allows us to gain deeper insights into the intricate interplay between the immune system and diseases. This, in turn, enables us to develop more targeted and personalized approaches for diagnosis and treatment," explained co-study leader Kaan Boztug.
Co-study leader Jörg Menche explained,"We increasingly recognized the conceptual and practical limitations of the traditional paradigm of 'one gene, one disease' in the research of. This hinders our understanding of the complex molecular network through which the components of the immune system are orchestrated."
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