Vaginal seeding is safe and seems to benefit infants delivered by the surgery — but larger trials are needed.
Credit: APHP-Cochin-Voisin/Phanie/Science Photo Library
In 2016, a team co-led by Clemente published a trial of vaginal seeding: four infants who underwent the procedure successfully acquired microbes from their mother’s swabs and had microbiomes that resembled those of children delivered vaginallyAlthough the study did not look at the long-term effects of vaginal seeding, the findings led to an avalanche of interest in the procedure, says Clemente.
“It’s very exciting and promising,” says Alexander Khoruts, a physician-scientist at the University of Minnesota in Minneapolis. But it’s not clear whether the neurodevelopmental differences will turn out to be meaningful, because the brain changes so much as children develop. “Early delay by a couple months may not translate into anything meaningful at 18 years.”
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