Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model AnimalModel Nanoparticles SARSCoV2 Coronavirus Disease COVID PNASNews
By Dr. Priyom Bose, Ph.D.Jan 24 2023Reviewed by Emily Henderson, B.Sc. The repeated zoonotic spillovers of α- and β-coronaviruses have significantly increased morbidity and mortality worldwide. The severe acute respiratory syndrome coronavirus-2 spillover is likely from a bat or a pangolin. This highly infectious virus has resulted in the coronavirus disease 2019 pandemic, claiming more than 6.64 million lives worldwide.
The S1 subunit contains a receptor-binding domain and an N-terminal domain , and two S1 subdomains . The RBD domain is responsible for over 90% of neutralizing activity, elucidated from studying COVID-19 convalescent patients and vaccinated individuals. Interestingly, RBD monomer, dimer, and trimer were observed to trigger potent Ab responses. In addition, self-assembling multivalent RBD nanoparticles exhibited induction of significant immune responses.
Despite their low sequence similarity, PCNA subunits have a similar structure, contain around 250 amino acids, and are arranged in a sequential manner. PCNA1 and PCNA2 combine and recruit PCNA3 to form a heterotrimer whose dissociation constants are between micromolar and nanomolar ranges. Study Findings Based on antigenic characterization, six heterologous antigens were found to be evenly distributed on 6RBD-np. This finding highlighted the advantages of using the PCNA subunits for developing mosaic multivalent antigens compared to previously used stochastic assembly platforms.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Potent small-molecule inhibitors against SARS-CoV, MERS-CoV, and SARS-CoV-2Potent small-molecule inhibitors against SARS-CoV, MERS-CoV, and SARS-CoV-2 MERS CoV SmallMolecule SARS SARSCoV2 Coronavirus Disease COVID biorxivpreprint SamuelMerrittU nybloodcenter
Read more »
Offshore worker sparks rescue mission after vanishing 100 miles off Scots coastConcerns were reportedly raised on Sunday night after the man was reported missing from an offshore installation around 100 miles south-east of Aberdeen.
Read more »
TikTok’s 100 Envelopes Challenge Works—Sort OfThe benefit of the '100 Envelopes Challenge' is that it starts small and encourages constant, conscious saving that builds quickly. But the trend may not be the most effective way to put away money, according to financial experts
Read more »
100-year-old woman says secret to a long life is 'not speaking to strange men'100-year-old Olive Westerman has revealed the secret to long and happy life is to ‘avoid talking to strange men'. Absolutely superb advice, quite frankly.
Read more »
Portishead boy joins Mensa after teaching himself to read aged two“Well mummy, I’m counting in Mandarin” Boy who taught himself to read as a toddler accepted as the UK's youngest member of Mensa
Read more »
SARS-CoV-2 Omicron XBB.1.5, CA.3.1, and CH.1.1 exhibit remarkable antibody resistanceIn a recent study posted to bioRxiv* preprint server, researchers at Ohio State University examined the degree of neutralizing antibody (nAb) evasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB.1.5, CA.3.1, and CH.1.1 subvariants.
Read more »