More depressed patients than previously estimated could have increased activation of their immune system kingscollegelon
involved in this association, the research could pave the way to better identify those patients with an immune component to their depression which would potentially help to provide more personalized approaches to treatment and management of MDD.builds on previous findings that there is an activated immune response in many people with MDD.
168 participants were sourced from the Biomarkers in Depression Study . 128 of them had a confirmed diagnosis of MDD and they were then divided into three subgroups according to their levels of CRP in the blood. When comparing MDD patients who did and didn't have elevated levels of CRP in their blood, there were no differences in the expression of these 16 genes, suggesting this pattern of expression was independent of CRP levels and potentially underlying a different mechanism.
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