A team of researchers have mapped almost 6,000 proteins from different cell types within the eye by analyzing tiny drops of eye fluid that are routinely removed during surgery. The researchers used an AI model to create a 'proteomic clock' from this data that can predict a healthy person's age based on their protein profile.
The clock revealed that diseases such as diabetic retinopathy and uveitis cause accelerated aging within specific cell types. Surprisingly, the researchers also detected proteins associated with Parkinson's disease within eye fluid, which they say could offer a pathway to earlier Parkinson's diagnoses.A team of researchers have mapped almost 6,000 proteins from different cell types within the eye by analyzing tiny drops of eye fluid that are routinely removed during surgery.
To map protein production by different types of cells within the eye, Mahajan's team used a high-resolution method to characterize proteins in 120 liquid biopsies taken from the aqueous or vitreous humor of patients undergoing eye surgery. Altogether, they identified 5,953 proteins -- ten times the number of proteins previously characterized in similar studies. Using a software tool they created called TEMPO, the researchers were able to trace each protein back to specific cell types.
The authors say that these results suggest that aging may be organ- or even cell-specific, which could yield advances in precision medicine and clinical trial design."These findings demonstrate that our organs are aging at different rates," says first author and ophthalmologist Julian Wolf of Stanford University."The use of targeted anti-aging drugs could be the next step in preventative, precision medicine.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Irritable Bowel Syndrome News -- ScienceDailyRead the latest research on irritable bowel syndrome, IBS.
Read more »
Learn programming by playing | ScienceDailyThe changing information technology industry, latest artificial intelligence applications, high demand for IT professionals, and evolving need for learning are leading to the search for innovations in education that will allow current and future employees to acquire knowledge in a contemporary and accessible way.
Read more »
Prostate Health News -- ScienceDailyLatest research news on prostate health. Find out about prostate cancer symptoms, enlarged prostate and other prostate problems.
Read more »
You don't lose if you snooze | ScienceDailyIt is often claimed that using the snooze button can have negative effects on sleep and cognitive processes, but there has been no direct evidence to this effect. New research shows that snoozing may actually support the waking process for regular snoozers.
Read more »
Lyme Disease News -- ScienceDailyLyme Disease News. Read the latest research on Lyme disease symptoms, diagnosis, prevention and treatment options.
Read more »
Computer Graphics News -- ScienceDailyComputer Graphics. Read the latest news in computer graphics, 3-D imaging and more.
Read more »