The researchers have developed a new technique called Region Capture Micro-C (RCMC), which uses targeted sequencing to generate ultra-high-resolution 3D genome structure maps.
Region Capture Micro-C , a new technique created by MIT researchers to map the 3D organization of the, provides unparalleled resolution at a far cheaper cost. The MIT researchers used Micro-C, which fragments the genome using the enzyme micrococcal nuclease, to acquire the high resolution required to map particular connections between genes and regulatory regions.
The number of potential genomic locations is reduced by a factor of 1,000 by concentrating on regions of the genome that contain genes of interest, and the cost of sequencing is reduced by a factor of 100,000, or around $1,000. In a recent , the scientists employed RCMC to investigate five locations with sizes ranging from a few hundred thousand to nearly 2 million base pairs.They discovered numerous enhancers that interact with Sox2 as well as previously unknown relationships between neighboring genes and enhancers after collecting and sequencing theregions of interest.
The MIT team intends to collaborate with scientists at Harvard Medical School to investigate variants linked to metabolic disorders and with scientists at Boston Children's Hospital to apply this type of analysis to genomic regions that have been connected with blood disorders in genome-wide association studies.For a quarter of the price of other published techniques, RCMC produces maps that are 100 times more information-rich by concentrating on regions spanning a few million base pairs.
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