Because metal-organic frameworks (MOFs) — highly porous metal complexes — are so structurally and chemically diverse, they could be used for many applications, such as drug delivery and environmental clean-up. But researchers still need to get a better understanding of how they function, especially when embedded in polymers.
Researchers have now developed and characterized nitric oxide -storing MOFs embedded in a thin film with novel antibacterial potential.Because metal-organic frameworks -- highly porous metal complexes -- are so structurally and chemically diverse, they could be used for many applications, such as drug delivery and environmental clean-up. But researchers still need to get a better understanding of how they function, especially when embedded in polymers.
To test this, they created three membranes in collaboration with researchers at Colorado State University containing a nickel MOF called CPO-27-Ni, a copper MOF called CuBTTri, or both. Next, using their cryogenic FIB-SEM technique, they saw particles of each MOF in greater detail than with other imaging methods. The images also showed that the metal complexes were distributed evenly throughout the membranes and did not overlap.
The researchers say that the nickel and copper MOFs combined to create a composite material that achieved an optimal, two-stage NO delivery system. They suggest that this two-phase delivery might be useful in medical devices, providing both immediate antibacterial effects and long-term prevention of microbial fouling.Romy Ettlinger, Simon M. Vornholt, Madeline C. Roach, Robert R. Tuttle, Jonathan Thai, Maadhav Kothari, Markus Boese, Andy Holwell, Morven J. Duncan, Melissa Reynolds, Russell E.
Materials consisting of inorganic and organic components can combine the best of two worlds: under certain circumstances, the so-called MOFs - short for metal-organic frameworks - are structured in ...
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Metal-organic frameworks could someday deliver antibacterial nitric oxideBecause metal-organic frameworks (MOFs)—highly porous metal complexes—are so structurally and chemically diverse, they could be used for many applications, such as drug delivery and environmental clean-up. But researchers still need to get a better understanding of how they function, especially when embedded in polymers.
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