“Not just five years, but 10,15, 20 years before diagnosis, there are changes in the brain that are early signals of the disease.”
The unexpected finding by U of A scientists speaks to the importance of taking differences between men and women into account when diagnosing and treating Alzheimer’s, said Roger Dixon, a professor of psychology in theStart your day with a roundup of B.C.-focused news and opinion delivered straight to your inbox at 7 a.m., Monday to Friday.By clicking on the sign up button you consent to receive the above newsletter from Postmedia Network Inc.
The study shows a sharp decline in memory for men with BIN1 genetic risk as well as poor vascular health, but not for women.Article content “We first confirmed that good vascular health was associated with higher memory level and shallower decline and males were more severely affected by worsening PP in both memory performance and longitudinal decline,” reads the study published in theMultiple risk factors that can lead to Alzheimer’s disease but with the right data, Dixon said, researchers can track and identify who is most at risk.
But for “those with BIN1 genetic risk, even good pulse pressure couldn’t protect them from memory loss,” and “for males with BIN1 genetic risk as well as poor vascular health, the slopes were a lot steeper, showing a sharp decline in memory, while for females it did not.” This finding is noteable also because women are diagnosed with Alzheimer’s disease more often than men in part because they live longer and there are other neurobiological and hormonal changes in midlife that also play a role.“What we are doing here is finding subtypes, as defined by these risk factors, and identifying which ones are most likely to benefit from what kind of risk intervention or risk reduction intervention.
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Men more than women affected by key Alzheimer's risk factors: U of A sudy“Not just five years, but 10,15, 20 years before diagnosis, there are changes in the brain that are early signals of the disease.”
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