In a real-world population of patients with EGFR-mutant advanced lung cancer, overall survival was much worse in patients who would not have been eligible for the pivotal FLAURA trial.
at the 2024 American Society of Clinical Oncology annual meeting, after the trial demonstrated a 33.5-month progression-free survival benefit in patients with EGFR-mutated unresectable stage 3 non–small cell lung cancer .
earlier this year, explored outcomes with first-line osimertinib among patients who would have been eligible for FLAURA as well as patients who would not have been eligible. At a median follow-up of 26.5 months, 70% of FLAURA-ineligible patients had died compared with 36% of FLAURA-eligible patients.
Because patients in the FLAURA-ineligible group have a worse prognosis overall, the difference between survival in this group and in the FLAURA-eligible patient group was not necessarily a surprise, said study author J. Connor Wells, MD, of the BC Cancer Agency in Vancouver, British Columbia, Canada.
Lung Carcinoma Cancer Of The Lung Non-Small Cell Lung Cancer Nsclc Small Cell Lung Cancer Small-Cell Lung Cancer Oat Cell Lung Cancer SCLC Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Biologic Therapy Biologics Antineoplastic Drug Anti-Cancer Agents Erlotinib Gefitinib Imatinib Rituximab Su11248 Sunitinib Trastuzumab Metastasis Metastatic Carcinoma
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