Exposure to airpollution during pregnancy increases risk for flu tamu
UFPs for 6 h for 13 days, followed by a three-day infection challenge. While our dose does approach a regulatory standard, the addition of an alternative dosing level surpassing the regulatory standard is warranted to determine a dose–response relationship between UFPs and PR8 viral infection. Second, our infection window is relatively narrow.
Collectively, our results are an important start to support clinical and regulatory interventions for protecting pregnant women and controlling UFPs, respectively. It is imperative to provide vaccination for pregnant women in urban cities, where influenza and UFPs have common hot spots.
]. Preventive measures limiting UFP exposure and promoting vaccination are warranted to protect maternal health.Male and female C57Bl/6N 8- to 10- week-old mice were kept in a 12-h light dark cycle and time mated in an AAALAC approved facility at Texas A&M Institute for Genomic Medicine. All approved protocols were followed according to the Texas A&M University Institutional Animal Care and Use Committee #2019–0025.
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