Marijuana Users Have Triple the Odds for Leg Artery Disease (Study)

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Marijuana Users Have Triple the Odds for Leg Artery Disease (Study)
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Much like cigarette smoking, marijuana use may raise risk for peripheral artery disease, with a new study finding that users had three times the risk of developing PAD.

MONDAY, May 15, 2023 -- Smoking cigarettes has long been linked to peripheral artery disease , a condition where the buildup of plaque narrows arteries and limits blood flow to the legs or arms.

“Marijuana users should seek early evaluation by a health care professional if they have symptoms such as leg pain while walking, slower/no hair growth and coldness in the leg as there seems to be an increased risk for developing PAD in this patient population,” said study authors Dr. Hirva Vyas from Hackensack University Medical Center in New Jersey and Dr. Harsh Jain, a resident with the Montefiore Health System in New York City.

The study found that marijuana users were at an increased risk even after controlling for some variables, including smoking cigarettes, Vyas and Jain said. Dr. Robert Page, a professor in the departments of clinical pharmacy and physical medicine at the University of Colorado Anschutz Medical Campus in Denver, cautioned that the study shows an association and not a cause-and-effect link.

Cannabis has, in past research, been shown to be linked to a number of other cardiovascular health issues in heavy smokers of the drug, Page said.“What it does suggest is that, to put it in layman's terms, is that THC can make platelets angry and when they get angry, they aggregate. And when they aggregate, that can lead to what we call thrombosis [a blood clot],” he explained.

“When you take that into account, these data are not surprising,” Page said. “I think it adds to the literature, particularly in younger adults, that we're seeing an increased risk for ischemic stroke and we're also seeing an increase in early first-time stroke in younger adults, between the ages of 18 to 40, where you wouldn't think of that."

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