Findings from a two-year study of nearly 2,400 solid organ transplant recipients, conducted by the Johns Hopkins Transplant Research Center (TRC) in collaboration with the New York University Center for Surgical and Applied Transplant Research, indicate spikes of post-vaccination SARS-CoV-2 viral infections (commonly known as COVID-19 breakthrough cases) remain common, yet hospitalization rates have dramatically dropped following the first wave of the virus' omicron subvariant.
"These results mirrored what medical institutions across the country were reporting for many U.S. populations, not just people who are immunocompromised," says senior study author William Werbel, M.D., Ph.D., assistant professor of medicine and associate director of the TRC's epidemiology and quantitative sciences at the Johns Hopkins University School of Medicine.
Werbel says just under a fifth of the study participants reported SARS-CoV-2 infections, and of those persons, 35 required hospitalization. He explains that the decrease was likely due to many factors, including growing population immunity , better disease management , more testing and, possibly, changes in the virus itself.
Werbel adds that the new study's findings"can guide counseling regarding the benefits of vaccination, and provide an evidence-based framing of risk and risk behaviors for populations most vulnerable to COVID, such as transplant patients."
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