Whole-genome sequencing of 1,013 clonal haematopoietic colonies from myeloproliferative neoplasms of 12 individuals reveals haematopoietic phylogenies and indicates that driver mutations are acquired sequentially, starting early in life.
. Time-based phylogenetic trees. Different coloured branches identify separate clades alongside light blue wild type colonies. The vertical axis represents age post conception with treatment received alongside. Driver mutations are depicted in the middle of the branches but may have occurred at any point between the start and end of the branches.
Extended Data Fig. 7 legend: Aberrant cell fractions in bulk blood samples and validation of selection estimates.. Plots showing aberrant cell fraction in colonies and bulk longitudinal mature blood cell samples. Colony samples were derived from peripheral blood or bone marrow mononuclear cells. Bulk mature blood cell samples comprised mostly peripheral blood granulocytes and occasionally, bone marrow derived granulocytes or mononuclear cells , and whole blood .
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Topological triple phase transition in non-Hermitian Floquet quasicrystals - NatureA triple phase transition, where changing a single parameter simultaneously gives rise to metal–insulator, topological and a parity–time symmetry-breaking phase transitions, is observed in non-Hermitian Floquet quasicrystals.
Read more »
Historical glacier change on Svalbard predicts doubling of mass loss by 2100 - NatureHistorical photographs, modern observations, and a simple space-for-time substitution approach predict that glacier mass loss from Svalbard is poised to double over the twenty-first century.
Read more »
Black-hole-triggered star formation in the dwarf galaxy Henize 2-10 - NatureOptical observations with a linear resolution of a few parsecs show that the outflow from the central black hole in the low-mass galaxy Henize 2-10 triggered a round of star formation.
Read more »
Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis - NatureAgeing alters the kinetics of translation elongation in both Caenorhabditis elegans and Saccharomyces cerevisiae.
Read more »
Enantiomer-dependent immunological response to chiral nanoparticles - NatureNanoparticles with different chiralities have different in vitro and in vivo effects on the immune system, suggesting new ways of creating vaccine adjuvants.
Read more »
7 Midwest cities to visit in 2022 for history buffs, nature enthusiasts, foodies and moreTravel to these Midwestern cities — from Detroit to Des Moines and Minneapolis to Galena — in 2022, to find great food, nature or small-town charm.
Read more »