The ancient advice to “feed a cold, starve a fever” has a limited evidence base, but new research highlights how feeding fat and sugar to a tumor could fuel its growth.
Only tumors in animals eating the low-calorie diet showed slower growth, implying that the tumors needed more than glucose to keep growing. Glucose levels were lower with both calorie restriction and the keto diet, but lipids also were lower with calorie restriction.
All cells, including cancer cells, use lipids to build their protective outer membranes. The increased lipid levels in the keto diet may have given tumors all the lipids they needed to build new cell membranes. The results suggest that the key to slowing cancer in these mice was to starve tumors of both glucose and lipids, as only the calorie-restricted diet did. The healthy tissues of the body still need these nutrients, one reason patients with cancer shouldn’t change their diets without clinical guidance. But the findings hint that using diet or drugs to restrict intake of some lipids or their use cells could be a path to starving a tumor without starving the person.New release, MIT.
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