Investigating tumor and gut microbiome traits that impact chemoradiation therapy in patients with cervical cancer.
By Pooja Toshniwal PahariaOct 24 2023Reviewed by Lily Ramsey, LLM In a recent study published in Cancer Cell, researchers combined deep microbial sequencing and targeted culturing of bacteria with in vitro assessments to investigate tumor and gut microbiome traits that impact chemoradiation therapy in patients with cervical cancer.
Detailed mechanistic investigation of tumor microbes, on the other hand, remains a considerable difficulty concerning most tumor types. The researchers used 16S rRNA data to perform linear discriminant analysis effect size on 43 patients to determine associations with the response to chemoradiation treatment. An additional 58 patients were recruited across two institutions to validate the association between L. iners with RFS.
Cell viability was also examined in Henrietta Lacks cells following IR utilizing cancer-derived and non-cancer-derived L. crispatus. L. crispatus did not induce resistance to treatment. Advanced stage, assessed using the International Federation of Gynecology and Obstetrics 2009 criteria, and poorer gut microbial diversity reduced RFS.
L. iners was an obligatory L-lactate maker and tumors with CC-L. iners+ were enriched with L-lactate. After CFS treatment, DNA damage was found in cervical cancer cells with CC-L. iners caused significant gene expression modifications compared to NC-L. iners.
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