Skin organoids offer a powerful platform for drug discovery in the ongoing fight against the virus formerly known as monkeypox.
A new model system for studying mpox virus infections in the laboratory is providing valuable insights into the virus's mechanisms of attack on skin cells, offering a potential catalyst in the quest to discover innovative drugs to combat this emerging pathogen.
People infected with the mpox virus typically develop rashes and skin lesions, often leading to scarring and disfigurement — and the lab-grown skin organoids now help show why. These genetic alterations likely compromise the skin's protective barrier, resulting in the characteristic lesions observed in infected people.
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