Johns Hopkins-led research finds early treatment with plasma from recovered COVID-19 patients reduces 'long COVID' risks, with inflammation-inducing interleukin-6 (IL6) playing a key role in symptom development. Findings from a nationwide, multicenter study led by Johns Hopkins Medicine and the J
that showed convalescent plasma is an effective and safe option as an early outpatient treatment for COVID-19. The latest study looked at the long-term outcomes of a large portion of the participants from the 2021 clinical trial.
For the latest study, the researchers used the cytokine and chemokine measurements, along with reports by patients of any post-COVID conditions at the 90-day examination, to determine if there was any association between early convalescent plasma therapy and long COVID symptoms. Statistical analyses were conducted to validate the findings, after adjusting for other factors that could make someone more prone to post-COVID conditions, such as demographics , competing diseases , and vaccine status.
Additionally, study participants who had higher-than-normal levels of one particular cytokine, interleukin-6 , at screening were more likely to be among those with post-COVID symptoms by day 90. IL6 is known to trigger an inflammatory response in humans.
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