Is COVID prematurely aging our immune systems? | SaltWire New research suggests repeated COVID infections may be prematurely aging human immune systems.
The worry is that people will be less able to hold off future bugs and pathogens like influenza, or that unsettled immune systems could lead to an increase in diabetes and other auto-immune diseases.
Her team has since published a small study showing abnormal white blood cell counts and high inflammation even in asymptomatic and mild “recoverees,” though the problem is much more pronounced in people with severe cases of COVID. T cells have a life cycle, Pirzada said. Naïve cells are those that haven’t yet responded to an infection. “Once a T cell commits to responding to one thing, it can’t respond to anything else,” Bowdish explained. “As we age, more and more of them become committed to responding to infections, or all the other things we might be exposed to, and fewer and fewer are available to respond to new threats.
The virus hyperactivates T cells, and, in severe cases, those overzealous cells can cause chronic inflammation that’s responsible for a lot of the harm done to the body, said T cell researcher Anthony Leonardi.that people with long COVID had persistent pieces of spike protein — the protein that studs the outside of the virus — in their blood up to a year, post-diagnosis, which could be a reservoir of infection.
But if people are losing naïve cells, they may be less likely to respond to other viruses or infections, “so that’s the major concern,” Bowdish said.
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