Injectable fatty acid copolymer ARA 3000 BETA shows therapeutic potential in treating osteoarthritis SciReports umontpellier osteoarthritis therapy fattyacid copolymer injectable
By Dr. Chinta SidharthanMay 16 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Scientific Reports Journal, researchers examined the therapeutic potential of an injectable copolymer of stearic, palmitic, and oleic acids known as ARA 3,000 BETA for treating osteoarthritis.
The development and progression of osteoarthritis are linked to elevated levels of matrix metalloproteinases and pro-inflammatory cytokines. Oleic and palmitic acids, which are forms of omega-9 monounsaturated fatty acids and saturated fatty acids, respectively, are two of the three most abundant fatty acids found in the synovial fluid of joints and have exhibited anti-inflammatory properties.
The last group was the intra-muscular group, in which the mice were injected 50 µL of ARA 3,000 BETA through the Anterior tibialis muscle on the third, 11th, 18th, and 25th days. Results The results indicated that intra-arterial injections of ARA 3,000 BETA showed strong protective properties against cartilage degradations. The histological analysis of the knee joints showed protective effects after intra-arterial and intra-muscular injections of ARA 3,000 BETA.
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