Influenza vaccine effectiveness during the 2021–2022 influenza season in the United States CIDJournal CDCgov VUMChealth KPWaResearch umichsph vaccine influenza flu vaccination
By Neha MathurDec 15 2022Reviewed by Danielle Ellis, B.Sc. In a recent article published in Clinical Infectious Diseases, researchers estimated influenza vaccine effectiveness in patients aged ≥6 months seeking outpatient care for acute respiratory illness due to the influenza A virus between October 2021 and April 2022 in the United States .
The team collected oropharyngeal swabs but only nasal swabs from children under two years. They used them to test for influenza and coronavirus disease 2019 via reverse-transcriptase polymerase chain reaction . They included those who had cough or fever, sought clinical testing within seven days of illness onset, and excluded those who were SARS-CoV-2-positive from the VE analysis. The control group comprised patients testing negative for influenza and SARS-CoV-2.
Although 7031 participants enrolled in the study, 6244 participants made it to the final dataset. Of these, 7% tested positive for influenza, and only 440 were A cases. Whole genome sequencing characterized that 47% of the influenza A cases belonged to 3C.2a1b subclade 2a.2.
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