In the hunt for a male contraceptive, scientists look to stop sperm in their tracks

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In the hunt for a male contraceptive, scientists look to stop sperm in their tracks
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For decades birth control research focused on women. Now there's a new push to develop gels, pills or other products that could keep men from getting their partners pregnant. | via NPR

Condoms have been used to prevent pregnancy since the Middle Ages, with the rubber version arriving in the industrial mid-1800s. Over the years, they've become more effective and comfortable to use.

Dr. Page's study enrolls couples – nearly 450 of them worldwide. Having the woman involved too means"she's taking on consent as well as him, and they're really both participants," Page says.run in phases. In the first phase, the man applies the gel every day, but the couple still uses another form of contraception when they have intercourse. During this phase, researchers are periodically monitoring the man's sperm count.

In the 1990s, the World Health Organization sponsored trials for male hormonal contraceptive — where men were given high doses of testosterone — but those drugs never came to market. Researchers thought they weren't effective enough to sell, and side effects were serious, including toxicity for the heart, liver and kidney, and a potential increased risk of prostate cancer.

"The male reproductive system is really cool in that there's hundreds and hundreds of links in this chain, [so] that if you take out any one of them, you end up with effectively an infertile man," Logan says.is a gel that's injected into the vas deferens– the tube that carries sperm to the urethra in preparation for ejaculation– and blocks the transport of sperm. Logan says it could be like a reversible alternative to a vasectomy.

Another barrier to bringing male contraceptives to market is the rate of efficacy. Female contraceptive implants and IUDs are 99% effective, and birth control pills are 93% effective, according to Planned Parenthood. Male contraceptives may have to be just as good at preventing pregnancy in order to sell.

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