The five rat recipients witnessed normal organ function after 30 days of receiving the kidneys. Find out more at 🚀 engineering interestingengineering
In fact, the official release highlights that roughly 20 percent of donated kidneys can't be transplanted because the organs cannot be kept on ice for an extended period of time.
This is where the possibility of freezing the organ comes into play, although it comes with its own set of complications. This approach extends the storage duration of organs, but the ice crystals that form between cells might harm the tissue, rendering it worthless. Another alternative for long-term storage is cryopreservation methods such as vitrification. Using chemicals, this approach enables quicker organ cooling at very low temperatures. However, this has the disadvantage of rewarming the organ, which often results in uneven heating.To solve the uneven heating issues, the team has developed a specialized nano-warming process that warms the organ inside out.
The new rewarming technique involves using iron oxide nanoparticles added to the cryoprotectant chemical. These nanoparticles, which act like tiny heaters, are dispersed throughout the organ’s blood vessels after applying magnetic fields. Thereby rewarming up the organ uniformly. The scientists demonstrated this approach effectively by cryogenically preserving rat kidneys for up to 100 days. The organ was then rewarmed without any damage before being transplanted into rats.“This is the first time anyone has published a robust protocol for long-term storage, rewarming, and successful transplantation of a functional preserved organ in an animal,” said John Bischof, the study’s co-senior author, in an official release.
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