Recent findings unlock the potential of high-pixel-resolution single-photon avalanche diode cameras in multispeckle diffuse correlation spectroscopy. Assessing the circulation of blood to the brain can provide significant insights into its functioning. A surge in blood flow often corresponds to n
Quanticam sensor comprises a large sensor array for multispeckle imaging, resulting in a signal-to-noise ratio gain of 110 over a single-pixel system. Credit: Meta Platforms Inc.avalanche diode cameras in multispeckle diffuse correlation spectroscopy.
More precisely, devices based on DCS function by determining statistical attributes of the scattered light, which results in a speckle pattern. This is a random arrangement of luminous and dim spots produced when laser light scatters off a rough surface. Given that blood flow influences this pattern in a statistically foreseeable manner, DCS can be utilized as a surrogate measurement method.
This development promises multispeckle DCS instruments with much higher sensitivity. However, handling the extremely high data rates of modern SPAD cameras, which exceed the maximum data transfer rates of commonly used communication protocols, is quite challenging. This bottleneck has limited the scalability of SPAD cameras to higher pixel resolutions, hindering the development of better multispeckle DCS techniques.
It calculated 12,288 autocorrelations — one of the most time-consuming computations involved in multispeckle DCS — in real time, from the SPAD array output. In this way, the team managed to shift the computational burden from the host computing system to the hardware directly connected to the SPAD sensors. This alleviated the need for high computational power and extremely fast data transfer rates between the multispeckle DSC system and the host system upon which the data is visualized.
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