Impact of maternal COVID-19 on neonatal brain development AmerAcadPeds umiamimedicine covid COVID19 SARSCoV2 neonatal braininjury casestudy evidence research news
By Bhavana KunkalikarApr 10 2023Reviewed by Lily Ramsey, LLM In a recent case report published in the Pediatrics journal, researchers described two coronavirus disease 2019 -infected neonate cases exhibiting early-onset seizures and acquired microcephaly over time.
One infant suffered a sudden death aged 13 months and had significant brain damage, including loss of white matter, vacuolization, and gliosis, as determined during autopsy. A cesarean section was performed for maternal indications at 32 weeks of gestation after administering antenatal corticosteroids to facilitate fetal lung maturation.
Related StoriesThe infant presented COVID-19 immunoglobulin -G and combined IgA, IgM, and IgG reactivity towards a recombinant SARS-CoV-2 spike protein derivative and elevated levels of cytokines and inflammatory markers in their blood. Case report 2: full-term infant A Hispanic female infant with a gestational age of 39 weeks was born to a 20-year-old first-time mother. The mother had tested positive for asymptomatic SARS-CoV-2 in the second trimester but later tested negative.
Diffuse-restricted diffusion characterized by a low apparent diffusion coefficient was observed across the supratentorial brain as per the brain magnetic resonance imaging taken on day four, while the medial temporal and basal ganglia lobes were spared.
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