Real-world data from a preprint study confirm phase 3 results showing an OS benefit when immunotherapy is added to tyrosine kinase inhibitors and for immunotherapy-based combinations to treat metastatic renal cell carcinoma. rccsm
Progression-free survival was significantly improved with TKI- immunotherapy combinations compared with both TKI monotherapy and immunotherapy combinations .
Median overall survival was also not reached for first-line immunotherapy combination therapy, but the TKI-immunotherapy combination showed a numerical advantage . Investigators were also unable to confirm the significant overall survival improvement over TKI monotherapy in Checkmate 214 among intermediate/low-risk patients.
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