HPV, particularly high-risk variants, and metabolic syndrome (MetS) significantly increase all-cause mortality risk in women, underscoring the need for further research into their combined effects.
By Hugo Francisco de SouzaMar 13 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal PLOS One, researchers investigated the associations between human papillomavirus and metabolic syndrome and the impacts of these comorbidities on the all-cause mortality risk of clinically diagnosed HPV and MetS men and women.
HPV, MetS, and their potential associations Human papillomavirus is an umbrella term referring to more than 200 closely related viral strains, which together account for the most prevalent sexually transmitted infection in the world. Alarmingly, some HPVs have been found to act as carcinogens in a number of malignancies, a concern exacerbated by the lack of a cure for these conditions and the increasing global prevalence of the disease.
About the study The present study aims to evaluate the combined impacts of HVP and MetS on all-cause mortality risk across both male and female sexes. Data for the study was obtained from the United States National Health and Nutrition Examination Survey , a publicly available, long-term, large cohort population-based study of adult Americans irrespective of age and ethnicity.
Study findings Of the 71,058 participants enrolled in the NHANES cohort, 5,101 met the study inclusion criteria and were included in the final analyses. Females comprised 64% of the sample cohort, with women aged 18-24 representing half the total number of identified 'high-risk HPV' patients. Surprisingly, males in the same age group, especially those with higher educational qualifications and non-smokers, were the cohort with the most 'no HPV' representation.
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