While oral antihistamines, intranasal corticosteroids, and other medications provide symptomatic allergic rhinitis relief, allergen immunotherapy is the only available treatment that modifies the course of the disease.
International Forum of Allergy & RhinologySLIT's safety and efficacy are well established, the authors write. But many of the published clinical trials of SLIT involve monitoring, which may affect patient behavior. So researchers don't know how many patients continue in real life with SLIT for its prescribed duration of 3-5 years or longer.
26 studies reported persistence rates — continued therapy without being lost to follow-up — between 7.0% and 88.7% Rates of real-world SLIT persistence and adherence in the studies ranged widely for several reasons and precluded meta-analysis, the authors note. Studies varied greatly in participant characteristics, allergies treated, SLIT regimens, locations, and sample sizes. SLIT regimens varied in allergen numbers, drug forms, dosing schedules, and seasons. Study design and quality, follow-up duration, data collection methods, and statistical reporting, also differed.
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