High triglyceride-glucose index and stress hyperglycemia ratio as predictors of adverse cardiac events in patients with coronary chronic total occlusion: a large-scale prospective cohort study - Cardiovascular Diabetology

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High triglyceride-glucose index and stress hyperglycemia ratio as predictors of adverse cardiac events in patients with coronary chronic total occlusion: a large-scale prospective cohort study - Cardiovascular Diabetology
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A study published in Cardiovascular Diabetology finds that a high triglyceride index and a high stress hyperglycemia ratio are significantly correlated with poor prognosis in patients with coronary chronic total occlusion.

After discharge, participants were followed up at 6-month intervals until December 31, 2021. Data for endpoints were obtained from medical records, clinical visits, and/or telephone interviews by trained investigators who were blinded to the clinical data.

We further determined the association of the TyG index and SHR with the risk of clinical outcomes in patients with various glucose metabolism statuses and procedural outcomes . Categories were all based on the tertiles of the TyG index or SHR. Moreover, we examined the effect of the TyG index and SHR on the clinical outcomes through subgroup analysis based on important clinical variables, such as age, sex, BMI, smoking, dyslipidaemia, hypertension, HF with low LVEF , renal dysfunction, and AMI.

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Fish intake and pre-frailty in Norwegian older adults - a prospective cohort study: the Tromsø Study 1994–2016 - BMC GeriatricsFish intake and pre-frailty in Norwegian older adults - a prospective cohort study: the Tromsø Study 1994–2016 - BMC GeriatricsBackground Pre-frailty is an intermediate, potentially reversible state before the onset of frailty. Healthy dietary choices may prevent pre-frailty. Fish is included in most healthy diets, but little is known about the association between long-term habitual fish intake and pre-frailty. We aimed to elucidate the longitudinal association between the frequency of fish intake and pre-frailty in a cohort of older adults in Norway. Methods 4350 participants (52% women, ≥65 years at follow-up) were included in this prospective cohort study. Data was obtained from three waves of the population-based Tromsø Study in Norway; Tromsø4 (1994–1995), Tromsø6 (2007–2008) and Tromsø7 (follow-up, 2015–2016). Frailty status at follow-up was defined by a modified version of Fried’s phenotype. Fish intake was self-reported in the three surveys and assessed as three levels of frequency of intake: low (0–3 times/month), medium (1–3 times/week) and high (≥ 4 times/week). The fish–pre-frailty association was analysed using multivariable logistic regression in two ways; (1) frequency of intake of lean, fatty and total fish in Tromsø6 and pre-frailty at follow-up, and (2) patterns of total fish intake across the three surveys and pre-frailty at follow-up. Results At follow-up, 28% (n = 1124) were pre-frail. Participants with a higher frequency of lean, fatty and total fish intake had 28% (odds ratio (OR) = 0.72, 95% confidence interval (CI) = 0.53, 0.97), 37% (OR = 0.63, 95% CI = 0.43, 0.91) and 31% (OR = 0.69, 95% CI = 0.52, 0.91) lower odds of pre-frailty 8 years later compared with those with a low intake, respectively. A pattern of stable high fish intake over 21 years was associated with 41% (OR = 0.59, 95% CI = 0.38, 0.91) lower odds of pre-frailty compared with a stable low intake. Conclusions A higher frequency of intake of lean, fatty and total fish, and a pattern of consistent frequent fish intake over time, were associated with lower odds of pre-frailty in older community-dwelling
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