Healthy new mice have been born from eggs created from male mouse cells, boosting the idea that one day the same might be possible with human cells.
Last week, researchers told a genome-editing summit in London that healthy new mice had been born from eggs the team created from male mouse cells. The achievement,, gave a boost to the idea that one day the same might be possible with human cells, which could help individuals with infertility or allow two men to become biological parents of a baby. Yesterday, the full study behind that rodent reproductive advance.
When cultured for a long time, some of these male stem cells lose one of their two chromosomes, so researchers picked out those that had lost the Y chromosome and cultured them even longer. Eventually, some of those cells duplicated their remaining X chromosome, turning into XX, or biologically female, cells. Next, the researchers coaxed these stem cells to turn into oocytes, or eggs, by culturing them with ovarian cells.
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