Future decisions on how to manage COVID\u002D19 will require consideration of rapidly evolving data that requires a nimble response as information changes
on the horizon. A bivalent vaccine targeting both the original virus and the initial Omicron strain is almost ready for approval and distribution.
There rarely is a single definitive study that is relevant to all age groups or those with differing risk profiles. More commonly, divergent data is present in different studies and requires careful analysis to determine best practices. As there are evolving changes in disease burden, older data may no longer be useful for decision-making.
The landscape has changed as the virus has mutated. Case counts from testing are no longer reliable given the high rates of infection leading to cutbacks in testing and increased incidence of asymptomatic disease. Contact tracing is now similarly no longer useful. Indeed, the science that we rely on for decision-making is much less robust than it was in the past. Studies now being reported show much lower disease burden with Omicron in both vaccinated and unvaccinated people. We are, however, missing data to inform us on key decisions that will need to be made.
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