In a comprehensive study, researchers explored the causal relationship between the gut microbiome, serological urate levels, and gout using Mendelian randomization. The findings reveal that certain genetically predicted gut microbial taxa influence uric acid levels and gout development, and vice versa, suggesting the gut microbiome as a potential therapeutic target for gout.
By Pooja Toshniwal PahariaOct 9 2023Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Nutrients, researchers investigated the causal association between gut microbiome composition, gout, and serological urate values using Mendelian randomization .
About the study In the present study, researchers evaluated the impact of the gut microbiome on gout development. A meta-analysis of 763,813 people and 13,179 cases of gout yielded GWAS data on gout. SNPs linked with gut microbial taxa met the genome-wide significance cut-off to assure data robustness and the correctness of the findings. In addition, in line with prior research, SNPs related to the gut microbial taxa at a relatively broad threshold were selected as potential IVs.
Related StoriesAfter SNPs were harmonized and clumped, 28 single-nucleotide polymorphisms for gout were related to 20 taxa, while 29 SNPs for SUA were connected to 21 taxa. Twelve SNPs related to the complete GM were chosen as IVs from among the 196 GM taxa. With F-statistic values of more than 10, each SNP proved acceptable validity. There were five taxa related to SUA levels and ten to gout.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Gut health and leukemia: Exploring the crucial connection between diet and microbiota changesitemprop=description content=Gut microbiota's role in leukemia treatment responses is explored, with evidence suggesting diet and prebiotics may help manage microbiota alterations in patients. Diet during pregnancy, breastfeeding, and gut microbiota composition all intersect, potentially influencing leukemia risks and treatment outcomes.
Read more »
A mother mouse needs a diverse gut microbiome to form a healthy placentaThe bacteria found naturally in the digestive tract do a lot more than help digest food.
Read more »
Researchers identify link between gut bacteria and pre-clinical autoimmunity and aging in rheumatoid arthritisWhile the bacteria in the intestine are helpful for digesting food and fighting infections, they have long been suspected to play an essential role in triggering rheumatoid arthritis. This chronic inflammatory disorder affects the joints.
Read more »
Inside the pub that's a 'pillar of the community' after makeoverAs well as a new look, there's a new menu
Read more »
Can discrimination fuel obesity?itemprop=description content=Researchers have identified a potential link between experiences of discrimination and increased obesity risk by examining neural responses to food cues and gut metabolites. The study reveals that discrimination may influence unhealthy food choices, potentially disrupting the brain-gut connection, and suggests brain-targeted treatments or dietary changes as potential interventions.
Read more »