Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization - Microbiome

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Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization - Microbiome
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A study in MicrobiomeJ finds a causal relationship between low birth weight (LBW) and intestinal abnormalities, suggesting that restoring intestinal health in LBW infants may be achieved by targeting intestinal microbiota and bile acid metabolism.

]. On day 8, mice were sacrificed, and the entire colon was removed for length measurement. A 2-cm segment of colon descendens was collected and fixed in 4% paraformaldehyde for processing for histopathological examinations.A total of 10 multiparous sows were fed a corn-soybean meal-based diet to meet the NRC recommendations, with free access to the water throughout the entire experiment. Ten litters of Duroc × piglets were spontaneously delivered from sows after 113114 days of gestation.

]. Animals were randomly divided into five groups, including a control group, DSS group, DSS plus UDCA group, DSS plus macrophage depletion group, and DSS plus UDCA plus macrophage depletion group . On day 8, mice were sacrificed for sample collection and further analysis as mentioned above.A total of 40, 4-week-old healthy male C57BL/6 SPF mice were selected.

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