Gutmicrobiome can play key role in response to CAR-Tcell cancer immunotherapy DKFZ NatureMedicine
with certain forms of refractory and relapsing B-cell leukemias or lymphomas. But the therapy is hampered by considerable heterogeneity in responses. Complete and long-term remission is only achieved in up to 40% of patients.
This largest prospective study of its kind has followed 172 lymphoma patients previously failing multiple rounds of chemotherapy, from before CAR T immunotherapy initiation until two years later.
Importantly, exclusion of these confounding"high-risk" antibiotics-treated patients from the analysis enabled the researchers to identify strong and previously masked associations between the pre-CAR T therapy gut microbiome and subsequent clinical response to immunotherapy . In other words, the study showed that the pre- therapy gut microbiome in lymphoma patients can help predict their response to subsequent CD19 CAR-T therapy across populations, unless their microbiome is disrupted by wide-spectrum antibiotics.
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