Science, Space and Technology News 2024
Recent research led by Jerold Chun reveals that brain vesicles in Alzheimer’s patients carry unique genetic instructions that may contribute to disease progression. The study found a significant presence of full-length mRNAs and a unique gene expression pattern associated with inflammation, offering new insights into Alzheimer’s pathology and potential avenues for early detection and therapy. This portrait of extracellular vesicles was taken using confocal laser scanning microscopy.
“To corroborate the results of long-read sequencing in the human samples, we also looked at vesicles isolated from mouse cells,” says first author Linnea Ransom, Ph.D., a postdoctoral fellow at Sanford Burnham Prebys. “We found similar averages of between 78% and 86% full-length transcripts in three brain cell types: astrocytes, microglia, and neurons.”
The scientists determined that the 700 upregulated genes are associated with inflammation and immune system activation, which fits within known patterns of brain inflammation present in neurodegenerative diseases such as Alzheimer’s disease. The researchers also found many genes associated with Alzheimer’s disease in prior genome-wide association studies also were present in Alzheimer’s disease sEVs.
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