There were 4,098 cases of HFMD in Singapore in 2022. Read more at straitstimes.com.
SINGAPORE – Scientists from the Genome Institute of Singapore and the National University of Singapore’s Yong Loo Lin School of Medicine have used a gene-editing tool to combat the virus that causes hand, foot and mouth disease .
Crispr, or clustered regularly interspaced short palindromic repeats, is a gene-editing tool which has been used to alter DNA sequences. For their work, the team used Crispr-Cas13, a variation of the Crispr technology which alters a cell’s RNA. While common symptoms include fever, rashes and blisters, the disease can also lead to more serious complications such as encephalitis – or inflammation of the brain – or even death.
Another of the study’s authors, Dr Chew Wei Leong, said the Crispr-Cas13 cut the enteroviral RNA genome and mRNA into pieces, thus destroying the viruses. Both Cas13 and Cas9 are easily programmable towards new disease targets, and can act as “universal keys” to unlock cures for an even wider range of diseases, said Dr Chew.
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