MiRNA pathway regulates stress response in the amygdala.
A gene that could be responsible for driving anxiety symptoms has been identified by researchers from the Universities of Bristol and Exeter, which could potentially lead to the development of new therapeutic treatments.and environmental factors, with trauma being a significant contributor. By altering the gene, the researchers were able to lower anxiety levels in animal models, suggesting a potential association between this gene and the development of anxiety.
This gene is believed to play a role in the development of anxiety-related behaviors, and miR483-5p acts as a regulator of this gene, managing the stress response of the amygdala. As a result, the team suspects that this pathway may have a direct role in the manifestation of anxiety symptoms.The discoveries made by the team could potentially create opportunities for fresh treatment options for individuals who experience.
Understanding the brain circuitry that leads to anxiety disorders is a priority in combating the condition. The team hopes that the miR483-5p/Pgap2 pathway they identified in this study could provide a new option for the development of anti-anxiety therapies for complex psychiatric conditions in humans.
"miRNAs are strategically poised to control complex neuropsychiatric conditions such as anxiety. But the molecular and cellular mechanisms they use to regulate stress resilience and susceptibility were until now, largely unknown. The miR483-5p/Pgap2 pathway we identified in this study, activation of which exerts anxiety-reducing effects, offers huge potential for the development of anti-anxiety therapies for complex psychiatric conditions in humans," said Dr.
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